教 授    

吉永华,1978 年毕业于中国科技大学二系,曾历任中科院上海生理所实习研究员、助理研究员、副研究员、研究员、研究组负责人、博导;所学术委员会副主任、兼管所研究生处和科研计划处工作。2002 4 月任中科院上海生命科学院神经生物学重点实验室主任。2004 6 月任上海大学生命科学学院教授、副院长。兼任中国神经科学学会副理事长、中国生物物理学会常务理事、《生理学报》副主编、《生物物理学报》和《中国神经科学杂志-ChineseNeuroscience Bulletin》编委。曾任中国科学院神经生物学重点实验室、中科院昆明动物所动物模型与人类疾病机理重点实验室、中国科学院分子细胞生物学重点实验室以及复旦大学医学神经生物学国家重点实验室学术委员会委员。先后担任国家“973”项目‘脑功能与脑重大疾病的基础研究’(1999-2004)和‘脑功能的动态平衡调控’(2005-2010)的子课题组长,主持负责过多项国家自然科学基金项目,主要从事生物膜离子通道及其相关调制剂/配体的药理与毒理学研究。尤其针对国产资源特异性天然钠通道肽类毒素调制剂的生化和生理活性鉴定、钠通道药理功能与毒理学整合调控进行了系统的研究,已发表学术研究论文近140篇(其中被SCI收录论文80余篇,被国内外同行引用已突破1200余次),获准发明专利3项。1995 年获上海市首届自然科学牡丹奖,并被授予“牡丹优秀科学家”荣誉称号。1996 年获第3 届国家杰出青年基金资助,1997 年在日本静冈县立大学药学部任日本学术振兴会(JSPS)特别研究员,1998首届明治乳业生命科学奖,2008年度上海市自然科学二等奖,2009年度上海市科技精英提名奖。

 

附近三年项目相关论文、专著发表与奖励情况目录:

1)项目相关科研论文发表目录:

[1] Chai Z.F., Bai Z.T., Zhang X.Y., Liu T., Pang X.Y. and Ji Y.H.* (2007) Rat epileptic seizures  evoked  by BmK αIV and its possible mechanisms involved in sodium channels. Toxicol. Appl. Pharm. 220: 235242 [IF=4.722]

[2] Bai Z.T., Liu T. Pang X.Y., Chai Z.F., Yong-Hua Ji Y.H.* (2007) Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin,Brain Res. Bull. 73: 248–253 [IF=1.684]

[3] Liu T., Bai Z.T., Pang X.Y., Chai Z.F., Jiang F., Ji Y.H.* (2007) Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom, Eur. J. Pharm. 575:4656 [IF=2.522]

[4] Liu T., Pang X.Y., Bai Z.T., Chai Z.F., Jiang F., Ji Y.H.* (2007)  Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch,Toxicon,50:1073-1084 [IF=2.509]

[5] Tan M., Zhu M.M., Liu Y., Cheng H.W., Ji Y.H.* (2008) Effects of BmK AS on Nav1.2 expressed in Xenopus laevis oocytes, Cell Biol. Toxicol. 24:143–149 [IF=1.758]

[6] Liu T., Pang X.Y., Jiang F., Bai Z.T., Ji Y.H.* (2008) Anti-nociceptive effects induced by intrathecal injection of BmK AS, a polypeptide from the venom of Chinese-scorpion Buthus martensi Karsch, in rat formalin test, J. Ethnopharmacol.,117:332–338 [IF=2.049]

[7] Pang X.Y., Liu T., Jiang F., Ji Y.H.* (2008) Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom, Toxicon 51:9941007[IF=2.246]

[8] Shi J., He H.Q., Zhao R., Duan Y.H. Chen Y., Chen Y., Yang J., Zhang J.W., Shu X.Q., Ping Zheng P., Ji Y.H.* (2008) Inhibition of Martentoxin on Neuronal BK Channel Subtype (1+4): Implications for a Novel Interaction Model, Biophysical J.,94:37063713 [IF=4.627]

[9] Zhao R., Zhang X.Y., Yang J., Weng C.C., Jiang L.L., Zhang J.W., Shu X.Q., Ji Y.H.* (2008)  Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy, Brit.J.Pharmacol., 154:1116-1124 [IF=3.767]

[10] Liu T., Pang X.Y., Jiang F., Ji Y.H.* (2008) Involvement of spinal nitric oxide (NO) in rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch, Toxicon, 52:62–71 [IF=2.246]

[11] Feng X.H, Chen J.X., Yang Y.N., Ji Y.H.* (2008) Electrophysiological characterization of BmK I, an α-like scorpion toxin, on rNav1.5 expressed in HEK293t cells,, Toxicol in Vitro. 22:1582–1587  [IF=2.193]

[12] Liu T., Ji Y.H., (2008) The study of sodium channels involved in pain responses using specific modulators, Acta Physiologica Sinica, 60 (5):

[13] Bai Z.T., Liu T., Pang X.Y., Jiang F., Cheng M., Ji Y.H.* (2008) Functional depletion of capsaicin- sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion Buthus martensi Karch, Neurosci Res., 62:78–85 [IF=2.121]

[14] Zhu M.M., Tan M., Cheng H.W., Ji Y.H*. (2009) Scorpion -like toxin BmK I enhances membrane excitability by prevention of slow inactivation and deactivation of rat Nav1.2sodium channels expressed in Xenopus oocytes, Toxicol in Vitro.[IF=2.193]

[15] Mang-Mang Zhu, Jie Tao, Miao Tan, Hong-tian Yang, Yong-Hua Ji* (2009) U-shaped dose-dependent effects of BmK AS, a unique scorpion polypeptide toxin on the voltage-gated sodium channels Br J Pharmacol  [IF=4.902]

[16] Liu Y, Bai ZT, Feng XH, Li WP, Yang HT, Zhou JJ, Ji YH. (2009) Hyper-excitability in low threshold mechanical A fibers is potentially involved in scorpion BmK sting pain. Brain Res Bull. 2009 Apr 23.  [IF=2.281]

[17] Yang YN, Chen JX, Pang XY, Terakawa S, Chen X, Ji YH, Yong KL.Slow rise of intracellular Ca(2+) concentration in rat primary sensory neurons triggered by loureirin B. Sheng Li Xue Bao. 2009 Apr 25;61(2):115-20.

[18] Ping Zhang , Jian Shi , Bin Shen , Xu Li , Yongxiang Gao , Zhongliang Zhu ,Zhiqiang Zhu , Yonghua Ji , Maikun Teng , Liwen Niu (2009) Stejnihagin, a novel snake metalloproteinase from Trimeresurus stejnegeri venom, inhibited L-type Ca2þ channels  Toxicon 53 309–315  [IF=2.460]

[19] F.X. ChenY.R. QianY.H. DuanW.W. RenY. YangC.C. ZhangY.M. QiuY.H. Ji.(2009)      Down regulation of 67LR reduces the migratory activity of human glioma cells in vitro      Brain Research Bulletin.798):402-408 [ IF=2.281]

[20] Jiang F, Liu T, Cheng M, Pang XY, Bai ZT, Zhou JJ, Ji YH.(2009) Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch. Eur J Pharmacol [IF=2.787]

 

2)项目相关专著发表目录:

[1] 吉永华,白占涛等撰写的The nociceptive/antinociceptive effects of scorpion BmK toxins by specifically modulating sodium channels”一文被收编在法国出版的《Toxines at douleur》(ISBN 2-7430-0849-0)专著中。

[2 吉永华等撰写的Pharmacological and pathogenic integrative modulation of BmK neurotoxins targeting-especially on sodium channels综述文章被国际发行的《Animal Toxins:State of the Art:Perspectives of health and technology(ISBN:978-85-7041-735-0) 专著录用。

[3] 参与英文神经生物学教科参考书神经科学-《探索脑》中共四个章节内容的编译,主编:南京大学王建军教授, 2004年由高教出版社出版发行,书号ISBN 7-04-012194-8

[4] 参与《生物膜》教课参考书中关于膜离子通道章节的撰写,主编:杨福愉院士, 200510月由科学出版社出版发行,书号ISBN 7-03-015059-7

[5] 吉永华、白占涛撰写的题为“Modulation and cellular/molecular mechanism of sodium channel-specific modulators on nociception /antinociception”被神经科学进展()收录,书号:70401527892004年由高教出版社出版发行。

 

3)奖励情况目录:

[1]  吉永华教授获2009年度上海市科技精英提名奖:特异性钠通道调制剂/配体的系统性研究;

[2] 吉永华、张旭英、陈谨、刘通、赵荣获2008年度上海市自然科学二等奖(排名第一):特异性钠通道调制剂的研究。

 

4)承担科研项目情况

(1)  项目: 脑功能动态平衡研究, 国家科技部973 项目( G2006CB500800 ),2006.1-2010.12,吉永华主持子课题。

(2) 项目: 我国特有产毒动物多肽毒素的基础与应用基础研究,国家科技部973 项目( G2010CB529806 ),2010.1-2014.12,吉永华学术骨干。

(3) 项目:Martentoxin BK 通道新靶点与相应通道-配体相互作用新模式的研究,国家自然科学基金委面上项目(30772554),2008.12010.12,吉永华主持。

 

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